Search results for " metabolic pathways"

showing 3 items of 3 documents

Elucidating the molecular physiology of lantibiotic NAI-107 production in Microbispora ATCC-PTA-5024.

2016

Background The filamentous actinomycete Microbispora ATCC-PTA-5024 produces the lantibiotic NAI-107, which is an antibiotic peptide effective against multidrug-resistant Gram-positive bacteria. In actinomycetes, antibiotic production is often associated with a physiological differentiation program controlled by a complex regulatory and metabolic network that may be elucidated by the integration of genomic, proteomic and bioinformatic tools. Accordingly, an extensive evaluation of the proteomic changes associated with NAI-107 production was performed on Microbispora ATCC-PTA-5024 by combining two-dimensional difference in gel electrophoresis, mass spectrometry and gene ontology approaches. R…

0301 basic medicineProteomicsfood.ingredientMetabolic networkATP-binding cassette transporterActinomycetes Antibiotic production Differential proteomics 2D-DIGE and mass spectrometry Metabolic pathways Regulatory network Molecular and cellular functionsBiologyBioinformaticsProteomicsGram-Positive Bacteria03 medical and health sciencesfoodBacteriocinsActinomycetesGenetics2D-DIGE and mass spectrometryDifferential proteomics2. Zero hungerGel electrophoresisLipid metabolismRegulatory networkbiology.organism_classificationDrug Resistance MultipleAnti-Bacterial AgentsActinobacteriaMetabolic pathway030104 developmental biologyBiochemistryMicrobisporaMetabolic pathwaysATP-Binding Cassette TransportersAntibiotic productionPeptidesBacteriaMolecular and cellular functionsBiotechnologyResearch ArticleBMC genomics
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Urinary Metabolic Signatures Detect Recurrences in Non-Muscle Invasive Bladder Cancer

2019

Patients with non-muscle invasive bladder cancer (NMIBC) undergo lifelong monitoring based on repeated cystoscopy and urinary cytology due to the high recurrence rate of this tumor. Nevertheless, these techniques have some drawbacks, namely, low accuracy in detection of low-grade tumors, omission of pre-neoplastic lesions and carcinomas in situ (CIS), invasiveness, and high costs. This work aims to identify a urinary metabolomic signature of recurrence by proton Nuclear Magnetic Resonance (1H NMR) spectroscopy for the follow-up of NMIBC patients. To do this, changes in the urinary metabolome before and after transurethral resection (TUR) of tumors are analyzed and a Partial Least Square Dis…

0301 basic medicineCancer Researchmedicine.medical_specialtyUrinary systemmetaboliteUrologylcsh:RC254-282Article03 medical and health sciences0302 clinical medicineMetabolomicsCytologyMetabolomeMedicineUrologiametabolic pathwaysCàncerBladder cancermedicine.diagnostic_testbusiness.industryrecurrence predictionCystoscopymedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmetabolomicsnuclear magnetic resonance030104 developmental biologyOncology030220 oncology & carcinogenesisBiomarker (medicine)bladder cancerbiomarkerbusinessNon muscle invasivebiomarker bladder cancer metabolic pathways metabolite metabolomics nuclear magnetic resonance recurrence predictionCancers
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Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases.

2018

Background: Epidemiologic evidence indicates common risk factors, including air pollution exposure, for respiratory and cardiovascular diseases, suggesting the involvement of common altered molecular pathways. Objectives: The goal was to find intermediate metabolites or metabolic pathways that could be associated with both air pollutants and health outcomes (“meeting-in-the-middle”), thus shedding light on mechanisms and reinforcing causality. Methods: We applied a statistical approach named ‘meet-in-the-middle’ to untargeted metabolomics in two independent case-control studies nested in cohorts on adult-onset asthma (AOA) and cardio-cerebrovascular diseases (CCVD). We compared the results …

Air pollution Untargeted metabolomics Metabolic pathways Adult-onset asthma Cardio-cerebrovascular diseases0301 basic medicineChronic exposureAdultAir pollution exposureAir pollutionAir pollution010501 environmental sciencesmedicine.disease_cause01 natural sciencesSettore MED/01 - Statistica Medica03 medical and health sciencesAir pollutantsMD MultidisciplinarymedicineHumans0105 earth and related environmental sciencesGeneral Environmental ScienceAsthmaCardio-cerebrovascular diseasesAir PollutantsUntargeted metabolomicsOdds ratioEnvironmental Exposuremedicine.diseaseAsthmaMetabolic pathway030104 developmental biologyUntargeted metabolomicsMetabolic pathwaysCardiovascular DiseasesCase-Control StudiesImmunologyEXPOsOMICS ConsortiumEnvironmental SciencesMetabolic Networks and PathwaysAdult-onset asthmaEnvironment international
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